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Ambroxol hydrochloride

Ambroxol hydrochloride

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Packaging Details: 1kg/bag, 25kg/drum
Delivery Detail: within 7days after confirm the order

Specifications:
Product name: AMBROXOL HYDROCHLORIDE
CAS No.: 23828-92-4
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MP 233-234.5°C
storage temp.
2-8°C
Usage expectorant
Usage A metabolite of Bromohexine. Ambroxol Hydrochloride is a bronchosecretolytic drug.
Usage skin whitening, depigmentation agent
Usage Ambroxol is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to brea
Biological Activity Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC 50 values for tonic block are 35.2 and 111.5 μ M respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Analysis Test Specification Result
Description crystalline powder Conforms
Melting range 129°C~132°C 130.8°C-131°C
Loss on drying ≤0.5% 0.20 %
Specific rotation -58°~-62°(C=1,in CH3OH) -61.05°
Sulphated ash ≤0.1% 0.08 %
Heavy metals ≤10ppm Conforms
Chlorides ≤0.02% Conforms
Sulfates ≤0.02% Conforms
Fluorine 14.7%~17.9% 15.2%
Residual solvent Methanol ≤0.2%
Isopropanol ≤0.2%
Ethyl acetate≤0.2%
Chloroform ≤0.2%
0.0%
0.0%
0.0%
0.0%
Related substances
(HPLC)
Single impurity ≤0.2%
Total impurities ≤0.5%
0.05%
0.08%
Assay ≥99.5% 99.92%
Conclusion Accordance with the reference

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