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Aspirin powder

Acetylsalicylic acid

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Package and Storage:

Packaging Details: 25KG/BAG OR DRUM, as request
Delivery Detail: prompt shipment

Specifications:
Aspirin
1. GMP, DMF
2. BP/EP/USP

MP 134-136 °C(lit.)
Density 1.35
FP 250 °C
storage temp.
Store at RT.
Solubility H2O: 10 mg/mL at 37 °C
Water Solubility 3.3 g/L (20 ºC)
Stability Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc.
What’s acetylsalicylic acid? Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhydride. It is a white crystalline powder, odorless, stable in dry air. It will be slowly hydrolyzed to be salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction. Slightly soluble in water, soluble in ethanol, ethyl ether, chloroform, sodium hydroxide solution and sodium carbonate solution. Acetylsalicylic acid has antipyretic analgesic, anti-inflammatory and anti-rheumatism effect, that’s why it is often used for fever, headache, muscle pain, neuralgia, rheumatic fever, acute rheumatic arthritis, gout, etc.; also it has antiplatelet aggregation effect, and can be used for prevention of arterial thrombosis, atherosclerosis, transient cerebral ischemia and myocardial infarction; in addition, acetylsalicylic acid also can be used in the treatment of biliary tract roundworm disease and athlete’s foot.
【Pharmacological actions】Acetylsalicylic acid is one of the traditional antipyretic analgesics, as well as the role of platelet aggregation. Acetylsalicylic acid in the body has the characteristics of the antithrombotic, can reduce the formation of obstructive blood clots in surrounding arteries, and inhibit release of platelet response and endogenous ADP, 5 – HT, etc., therefore to inhibit second phase other than the first phase of platelet aggregation. The mechanism of action of acetylsalicylic acid is to make platelets cyclooxygenase acetylation, thus inhibiting the formation of ring peroxide, and TXA2 formation is also reduced as well. At the mean time make the platelet membrane protein acetylation, and inhibit platelet membrane enzyme, which helps to inhibit platelet function. As the cyclooxygenase is inhibited, it impacts blood vessel wall synthesized to be PGI2, the platelet TXA2 synthetic enzymes also to be inhibited; so it would impact formation of both TXA2 and PGI2 when it is large doses. Suitable for ischemic heart disease, after percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, prevent transient ischemic stroke, myocardial infarction and reduce the incidence of arrhythmia.
Applications 1.Acetylsalicylic acid is the raw material for rodenticide intermediates 4-hydroxycoumarin.
2.Used to make outdoor structural members and equipment parts exposed in highlights, such as the automobile body, agricultural machinery parts, meters and electric lamps, road marking, etc.
3.It is the earliest applied, the most popular and the most common antipyretic analgesics anti-rheumatism medicine, has aspects of pharmacological effects as antipyretic-analgesic and anti-inflammatory, anti-platelet aggregation and works quickly and effectively. Overdosage can be easily diagnosed and treated, with rare allergic reactions. Often used to cold fever, headache, neuralgia, joint ache, muscle pain, rheumatic fever, acute wet sex arthritis, rheumatoid arthritis and toothache, etc. Listed in National Essential Medicine List. Acetylsalicylic acid also works as an intermediate of other medicines.
Production method Acetylation of salicylic acid: add acetic anhydride (feeding ratio is 0.7889 times of the total salicylic acid) in reaction vessel, and then add two thirds of salicylic acid, stir it and temperature rises. React 40-60min in 81-82℃. Cool it to 81-82 ℃ and keep the temperature for 2h. When free salicylic acid is qualified, cool it to 13 ℃, precipitation crystallization, rejection filter, dry it in 65-70℃ air flow, then we get acetylsalicylic acid.
Toxicity grading High toxic
Acute toxicity Oral-rat LD50: 200 mg/kg; Oral-mice LD50: 250 mg/kg
Flammable hazardous characteristics Flammable in fire; irritant gas would be decomposed out when heated.
Handling and storage characteristics Warehouse needs to be ventiIative and dry with low temperature; separate it from oxidant and food additives.
Fire extinguishing agent Water fog, foam, carbon dioxide, sandy soil.
General Description Odorless white crystals or crystalline powder with a slightly bitter taste.
Air & Water Reactions Slowly hydrolyzes in moist air. Has been involved in dust cloud explosions. Water insoluble. Solution in water is acid to methyl red indicator.
Reactivity Profile The active ingredient in common aspirin. Incompatible with oxidizers and strong acids. Also incompatible with strong bases. May react with water or nucleophiles (e.g. amines and hydroxy groups). May also react with acetanilide, amidopyrine, phenazone, hexamine, iron salts, phenobarbitone sodium, quinine salts, potassium and sodium iodides, alkali hydroxides, carbonates, stearates and paracetanol.
Fire Hazard Acetylsalicylic acid is combustible.
Physical and chemical properties White power or colorless crystals; with acid taste and is stable in dry air, slowly hydrolyze into salicylic acid and acetic anhydride. Its solution shows an acid reaction. sparingly soluble in alcohol, chloroform or ether, slightly soluble in water or absolute ether, it dissolves in alkali hydroxide or alkali carbonate solution and decomposes at the same time.
Usage This product is an antipyretic ant rheumatic that is used to allay fever, headache, rheumatism, and rheumatoid arthritis. toothache and dysmenorrheal and as raw material for making anti-carcinogen.
Packaging (Net weight: 25KG)
Material: cardboard drum35*40cm  Gross weight: 27.2KG
paper bag in which is Polyethylene plastic 50×80cm  Gross weight: 25.2KG
Container packing explanation for 20’FCL/33CBM 20T for Bag without packing pallet , 18T for bag with packing pallet       1.6CBM/MT
15T for Drum without packing pallet, 11T for Drum with packing pallet     2.1CBM/MT
Storage Store in an airtight container and dry place, protected from light.
PURITY 99.50%-101.0%MIN 99.9%
APPEARANCE WHITE CRYSTAL OR CRYSTALLINE POWDER /WHITE POWDER WHITE CRYSTAL OR CRYSTALLINE POWDER
IDENTIFICATION POSITIVE POSITIVE
CLARITY AND COLOR OF SOLUTION CLEAR AND COLORLESS CLEAR AND COLORLESS
HEAVY  METALS LESS THAN 20PPM LESS THAN 20PPM
CHLORIDE LESS THAN 140PPM LESS THAN 140PPM
SUIFATE LESS THAN 0.04% LESS THAN 0.04%
LOSS ON DRYING LESS THAN 0.5% 0.09
SUIPHATED ASH LESS THAN 0.05% 0.03%
EASILY CARBONATED MATTER LESS THAN FLUID Q LESS THAN FLUID Q
FREE SALICYLIC ACID LESS THAN 0.05% LESS THAN 0.05%
RELATED COMPOUND LESS THAN 0.1% LESS THAN 0.1%
ORGANIC VOLATILE IMPURITIES UP TO STANDARD UP TO STANDARD

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