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Atenolol

Atenolol

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Atenolol raw material
CAS NO: 29122-68-7
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Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers (sometimes written β-blockers), a class of drugs used primarily in cardiovascular diseases.

MP 154°C
storage temp. Store at RT
Solubility H2O: 0.3 mg/mL
form powder
Biological Activity Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Usage Antihypertensive, Beta-adrenoceptor antagonist
Usage Selective b1 adrenergic receptor agonist, anti-hypertensive, anti-anginal, anti-arrhythmic
TEST STANDARDS
Description
White to Almost white powder.
Solubility Sparingly soluble in water; soluble in ethanol, slightly soluble in methylene chloride; Practically insoluble in ether.
Identification Complies with BP test B, C & D
Melting range Between 152 to 155
Appearance of Solution The solution is clear and not more than intensely coloured than degree 6 of the range of reference solution of the most appropriate colour.
Optical Rotation (at 20°C) Between +0.10 to 0.10
Chlorides NMT 0.1%
Related Substances
Individual Impurity
Total Impurities

NMT 0.25%
NMT 0.50%
Sulphated Ash NMT 0.1%
Loss On Drying
(At 105°C)
NMT 0.5%
Assay
(On dried basis)
Between 99.0% – 101.0%

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