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Azacitidine

Azacitidine

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Packaging Details: Accroding to customer demand.
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Specifications:
Product name: Azacitidine / CAS: 320-67-2

Items Specifications
MP
226-232 °C (dec.)(lit.)
alpha 40 º (C=1, H2O 22 ºC)
storage temp. 2-8°C
Water Solubility
0.5-1.0 g/100 mL at 21 ºC
General Description
White crystalline powder.
Air & Water Reactions
Slightly water soluble. Unstable in solution.
Reactivity Profile
5-Azacytidine is sensitive to light (may discolor). 5-Azacytidine is sensitive to oxidation. 5-Azacytidine is unstable in solution. 5-Azacytidine undergoes hydrolysis in aqueous buffers. 5-Azacytidine is incompatible with strong oxidizers.
Fire Hazard
Flash point data for 5-Azacytidine are not available; however, 5-Azacytidine is probably combustible.
Biological Activity
DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells.
Usage
A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase. Antineoplastic; Antimetabolite

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