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Candesartan Cilexetil

Candesartan Cilexetil

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Packaging Details: 5KG/DRUM; 25KG/DRUM
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PRODUCT NAME: Candesartan Cilexetil
CAS NUMBER: 145040-37-5

MP 168-170°C
storage temp.
-20°C Freezer
Application It can be used as pesticide and pharmaceutical intermediates.
It can be used as the raw material of antihypertensive drugs.
Usage Ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive
TEST STANDARD RESULT
Characters A white or almost white crystalline powder A white crystalline powder
Solubility Freely soluble in chloroform;
Sparingly soluble in anhydrous ethanol
Slightly soluble in acetonitrile
Practically insoluble in water
Conforms
Identification A. The retention time is consistent with that obtained with the reference
B. The UV spectrum is consistent with that obtained with the reference
C. The UV spectrum is consistent with that obtained with the reference
Conforms
Conforms
Conforms
Loss on drying NMT 0.5% 0.22%
Sulphated ash NMT 0.1% 0.08%
Heavy Metals NMT 0.001% <0.001%
Chlorides NMT 0.035% <0.035%
Related Substances (HPLC) Individual known impurity NMT 0.5%
Individual unknown impurity NMT 0.1%
Total impurities NMT 1.0%
0.08%
0.09%
0.26%
Residual solvents (GC) Methanol NMT 0.3%
Methanol NMT 0.3%
Ethyl acetate NMT 0.5%
n-Heptane NMT 0.5%
Dichloromethane NMT 0.06%
N,N-Dimethylformamide NMT 0.088%
Acetic acid NMT 0.5%
Not detected
Not detected
0.007%
Not detected
Not detected
Not detected
Not detected
Assay (HPLC) 98.0~102.0% 99.24%

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