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Celecoxib

Celecoxib

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Package and Storage:

Packaging Details: 25KG/paper barrel or packed according to the requirements of customers
Delivery Detail: 15 days after order

Specifications:
Product name: Celecoxib / CAS: 169590-42-5
Celecoxib is a sulfonamide nonsteroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

Items Specifications
MP
157-159°C
storage temp. Store at RT
Appearance White to off-white crystalline powder
Identification
A.The infrared absorption spectrum should meet with the reference spectrum
B.The retention time of sample major peak should meet with the retention time of reference substance major peak
Related substances
Any other individual impurity≤0.5%
Total impurities≤1.0%
Related substances
Ethanol≤0.5%
Ethyl trifluoroacetate≤0.5%
Water
≤0.5%
Residue On Ignition
≤0.2%
Heavy Metal
≤20ppm
Fluorine
14.2%-16.4%
Assay
98.0%-102.0%
Biological Activity
Selective cyclooxygenase-2 (COX-2) inhibitor (IC 50 values are 15 and 0.04 μ M for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo than SC 58121 (5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole ). Displays chemopreventive activity in in vivo tumor models.
Usage
For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis

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