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Chlortetracycline hydrochloride

Aureomycin hydrochloride

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Packaging Details: 25kg/drum.
Delivery Detail: 7days

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Aureomycin hydrochloride/Chlortetracycline hydrochloride. Please contact us if you want to know more about this product.
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MP 210-215 °C (dec.)(lit.)
storage temp.
2-8°C
Usage Chlortetracycline is an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial. Chlortetracycline hydrochloride is a salt prepared from chlortetracycline taking advantage of the basic dimethylamino group which protonates and readily forms the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, chlortetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. This compound contains an undetermined amount of epi-chlortetracycline
ITEMS SPECIFICATIONS RESULTS
Characters A yellow powder, slightly soluble in water and in calcohol. Dissoves in solutions of alkali hydroxides and carbonates. Complies
Identification A The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution. Complies
Identification B To about 2mg add 5ml of sulphuric acid R. A deep blue colour develops which becomes bluish-green. Add the solution to 2.5ml of water. The colour becomes brownish. Complies
Identification C Gives reaction of chlorides. Complies
pH 2.3 to 3.3(10mg/ml) 2.4
Specific optical rotation -235° to -250° (2.5mg/ml) -242°
Abosorbance Not greater than 0.40(5mg/ml, 460nm) 0.16
TC.HCl(Anhydrous Substance) Not more than 8.0% 5.0%
Heavy Metals Not more than 50ppm <50ppm
Water Not more than 2.0% 0.5%
Sulfated Ash Not more than 0.5% 0.1%
CTC.HCl(Anhydrous Substance) Not more than 89.5% 92.8%
TC.HCl+CTC.HCl(Anhydrous Substance) Not less than 94.5% and not more than 102.0% 97.8%
Related Substances
Impurity A Not more than 4.0% 0.9%
4-epi-isochlortetracycline Not more than 0.8% 0.3%
Demeclocycline Not more than 0.7% 0.1%
Total of 4-epi-isochlortetracycline and Demeclocycline Not more than 1.0% 0.4%
2-acetyl-2-decarboxamido-chlortetracycline Not more than 0.3% 0.1%
Any other detectable impurity Not more than 0.10% <0.10%
Formaldehyde Not more than 5ppm 1ppm
Sulfate Not more than 0.02% <0.02%
Iron Not more than 50ppm <50ppm
Magnesium Not more than 50ppm 7ppm
Zinc Not more than 10ppm 4ppm
Proteins Not more than 0.1% <0.1%
CRUDE FIBRE Not more than 0.1% <0.1%
Ethanol Not more than 5000ppm 2992ppm
Methanol Not more than 3000ppm Not detected
Conclusion The Subject Batch Complies with Ph.Eur. 7.0

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