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Cilnidipine

Cilnidipine

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Cilnidipine is the new calcium antagonist both L-and N-, the effect of was taken slowly and lastingly. It can been to, dispersible tablet and others.
Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels. However, the clinical benefits of cilnidipine and underlying mechanisms are incompletely understood.
Clinidipine is the new type of calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed  and approved to come into market for the first time and used for high blood pressure treatment in 1995. Compared with other calcium antagonists, clinidipine can act on the N-type calcium-channel that existing sympathetic nerve end besides acting on L-type calcium-channel that similar to most of the calcium antagonists.

MP 97-99°C
storage temp.
Store at +4°C
Biological Activity Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
Usage Antihypertensive; Dihydropyridine calcium channel blocker

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