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Dexibuprofen

Dexibuprofen

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Packaging Details: 25 kilos/drum
Delivery Detail: 7 days after order

Specifications:
PRODUCT NAME: Dexibuprofen
CAS NUMBER: 51146-56-6
Dexibuprofen is known to have an antiplatelet effect, though it is relatively mild and short-lived when compared with aspirin or other better-known antiplatelet drugs.

MP 49-53 °C(lit.)
alpha 57 º (c=2, EtOH)
refractive index 59 ° (C=2, EtOH)
FP >230 °F
storage temp.
Store at RT
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL
Water Solubility insoluble
Stability Stable. Incompatible with strong oxidizing agents.
Biological Activity Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC 50 values are 12 and 80 μ M respectively). Active isomer of ibuprofen.
Usage A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer
Test  Item Analysis  Specification Result
Description White crystalline powder White crystalline powder
Identification A: IR the spectrum is concordant with the spectrum of (S)-ibuprofen RS
B: The retention time of the principal peak is concordant with that of (S)-ibuprofen RS(HPLC)
C: Show two maximum absorption at 265nm and 273nm, two minimum absorption at 245nm and 271nm and a shoulder peak at 259nm.(UV)
Conforms

Conforms

Conforms

Melting point 50~54°C 50.9~51.7°C
Optical rotation +55°~ +60° +57.1°
Chloride ≤0.01% <0.1%
Loss on drying ≤0.5% 0.03%
Residue on ignition ≤0.1% 0.01%
Heavy metals ≤10ppm <10ppm
Residual solvents Toluene not more than 800 ppm 3ppm
Related Substances 2-(4-butylphenyl)propionic acid  <0.2%
4-isobutylacetophenone           <0.2%
Total impurities                        <0.7%
Any other individual impurity      <0.2%
Any unidentified impurity         <0.10%
R-ibuprofen                          ≤1.5%
Not detected
Not detected
0.03%
0.02%
Not detected
Conforms
Assay(Dry Basis) 98.5%~101.0% 100.0%
Conclusion Conform  to  In house Standard

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