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Edaravone

Edaravone

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Product name: Edaravone / CAS: 89-25-8
Edaravone is a neuroprotective agent used for the purpose of aiding neurological recovery following acute brain ischemia and subsequent cerebral infarction. It acts as a potent antioxidant and strongly scavenges free radicals, protecting against oxidative stress and neuronal apoptosis.
Edaravone has been shown to attenuate methamphetamine- and 6-OHDA-induced dopaminergic neurotoxicity in the striatum and substantia nigra, and does not affect methamphetamine-induced dopamine release or hyperthermia.It has also been demonstrated to protect against MPTP-mediated dopaminergic neurotoxicity to the substantia nigra, though notably not to the striatum.

Items Specifications
MP
126-128 °C(lit.)
BP 287 °C265 mm Hg(lit.)
Density 1,12 g/cm3
FP
191°C/17mm
storage temp.
Store at RT
Water Solubility
3 g/L (20 ºC)
Appearance
White to Off-white crystal powder
Identification
IR conforms to that of reference
HPLC Rt conforms to that of reference
Loss on drying
Not more than 1%
Residue on ignition
Not more than 0.2%
Ethanol(GC)
Not more than 0.2%
Heavy Metals (Pb)
Not more than 0.002%
Related substances (HPLC)
Total: Not more than 1%
Single: Not more than 0.5%
Assay(HPLC)
C10H10N2O contains not less than 98.5%
Biological Activity
A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.
Usage
Edaravone inhibits the disease activity in rheumatoid arthritis.

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