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Ibuprofen

Ibuprofen

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Packaging Details: 25 kilos/drum
Delivery Detail: 7 days after order

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Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for relief of symptoms of arthritis, fever, as an analgesic (pain reliever), especially where there is an inflammatory component, and dysmenorrhea. Ibuprofen is known to have an antiplatelet effect, though it is relatively mild and short-lived when compared with aspirin or other better-known antiplatelet drugs.

MP 77-78 °C(lit.)
BP 157 °C (4 mmHg)
storage temp.
-20°C Freezer
Water Solubility insoluble
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Product description Ibuprofen is a nonsteroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic and antipyretic effect is good, has less adverse reactions. Nowadays, it has already widely used in the world, and is to become one of the most popular over-the-counter medications in the world, and is listed as antipyretic analgesic three pillars products with aspirin, acetaminophen. In China, it is mainly used in the pain, rheumatism, etc., and not too much in the cold, antifebrile applications, much lower than the paracetamol and aspirin.
Ibuprofen was co-found by Dr Stewart Adams (later became a professor and was awarded a MBE) and his leadership team, scientific research expert CoLinBurrows, chemical expert Dr John Nicholson. The original research purpose was invention of a “super aspirin”, to replace drug of aspirin with less serious adverse reactions for the treatment of rheumatoid arthritis. And other drugs, such as Bute, has a greater risk of agranulocytosis occurred; Corticosteroid drugs, larger dosage than ordinary prescription dose brings the adrenal suppression and other adverse reactions, such as high risk of gastrointestinal ulcers, etc. Adams decided to find a drug with good gastrointestinal tolerance, this feature for all classes of non-steroidal anti-inflammatory drugs (nsaids) are particularly important on the current.
Benzyl acetate drugs caused the people’s interests. Although in dog trials found that some of these drugs have the risk of ulcer, but Adams realised that this phenomenon may be caused by the longer half-life of drug clearance. There is a compound in this class of drugs and the half-life of ibuprofen is shorter which is only 2 hours. In the screening of alternative medicine, though not the most effective, but is the safest. Ibuprofen become the most promising alternative drug of aspirin in 1964.
Indications 1, relieve rheumatoid arthritis, osteoarthritis, spinal arthritis, gouty arthritis, rheumatoid arthritis and other acute phase of chronic arthritis or continuous joint swelling pain symptom, etiology, treatment and control course of action.
2, treatment of non joint rheumatic pain every soft tissue, shoulder pain, tenosynovitis, slippery bursa phlogistic, muscle pain and injury pain after exercise, etc.
3, acute mild and moderate pain such as surgery, trauma, strain after, primary dysmenorrhea, toothache, headache, etc.
4, has antipyretic effect of adults and children fever.
Precautions 1, used in the late pregnant women can prolong pregnancy, prolonged labor and childbirth. Pregnant women and nursing mothers should not use.
2, has inhibition to the platelet aggregation, can prolong the bleeding time, but can disappear when stop drug in 24 hours.
3, can make the higher content of blood urea nitrogen and serum creatinine, creatinine clearance decreased.
4, any of the following situations should be used carefully:
the original bronchial asthma, and after medication may increase.
the cardiac insufficiency, high blood pressure, can cause the water retention and edema after starting drug therapy.
the haemophilia or other hemorrhagic diseases (including blood coagulation disorder and platelet dysfunction), after prolonged bleeding, bleeding tendency aggravating.
a history of peptic ulcer, the application of this product is easy to appear the gastrointestinal side effects, including produce new ulcers.
renal insufficiency after kidney increased adverse reactions, and even lead to kidney failure.
long-term medication should be regularly check blood picture, liver and kidney function.
Drug Interactions 1, drink alcohol or with other non-steroidal anti-inflammatory drugs available increase the gastrointestinal side effects, and have the risk of ulcer. Long term may be used with acetaminophen to increase of the side effects of kidney is dirty.
2, with acid aspirin or other drugs, not strengthen, and adverse reaction of gastrointestinal tract and an increased incidence of bleeding tendency.
3, with heparin and coumarin anticoagulants and platelet aggregation inhibition of drug use increase the risk of bleeding.
4, with cefuroxime sami unavailable, weakens the latter’s platoon sodium and step-down function.
5, with verapamil, nitrate benzene organism, increased blood concentrations of this product.
6, ibuprofen can heighten digoxin blood concentration, it must pay attention to adjust the dose of digoxin.
7, ibuprofen can strengthen antidiabetic drug (including oral medications).
8, this product may be used with antihypertensive drugs affect the antihypertensive effect of the latter.
9, probenecid can reduce the discharge of the product, increase the blood drug concentration, thus increasing toxicity, so with the use of reduced doses.
10, this product can reduce the discharge of methotrexate, and increase the blood concentration, even can reach toxic levels, so this product should not be with or high-dose methotrexate.
side effect 1, the digestive tract symptoms include indigestion, stomach burning sensation, stomach pain, nausea, vomiting, appeared in the long-term 16% users, withdrawal symptoms disappeared, the most drugs can be tolerance. A few (< 1%) in gastric ulcer and gastrointestinal bleeding, also have for ulcer perforation.
2, the nervous system symptoms such as headache, drowsiness, dizziness, tinnitus, rare in 1% ~ 1% of patients.
3, renal insufficiency is rare, in potentially nephropathy; But a few users can appear lower extremity edema.
4, other rare symptoms include skin rashes, bronchial asthma, elevated liver enzymes, leukopenia, etc.
5, medication should be stopped during such as gastrointestinal bleeding, liver, kidney damage, visual impairment, abnormal blood picture and allergic reaction, and so on and so forth.
Chemical property White crystalline powder. Melting point is 75-77 °C. Insoluble in water, soluble in ethanol, chloroform, ether and acetone.
Application Used as a PG synthetase inhibitors, has anti-inflammatory, analgesic and antipyretic effect. The curative effect of treating rheumatism and rheumatoid arthritis, less acetyl salicylic acid and bute. Is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis, etc. The goods ranked 13th order in drug sales of the United States in 1985.
Usage A selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency
ITEMS SPECIFICATIONS RESULTS
Appearance White crystalline powder or colorless crystalline powder Passes
Identification Accord With BP2007 Passes
Assay 98.5%~101.0% 99.97%
Melting point 75°C~78°C 77°C
Optical rotation -0.05°~+0.05° 0.00°
Heavy metals ≤ 0.001% <0.001%
Related substances
Impurity B ≤ 0.3% Passes
Any other impurity ≤ 0.3% Passes
Total of all impurities apart from impurity B ≤ 0.7% Passes
Impurity F ≤ 0.1% Not detected
Sulphated ash ≤ 0.1% 0.02%
Appearance of solution Accord With BP2007 Passes
Conclusion COMPLY WITH BP2007

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