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Ketoconazole

Ketoconazole

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Packaging Details: 25 kg/drum
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PRODUCT NAME: Ketoconazole
CAS NUMBER: 65277-42-1
Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.

MP 146°C
refractive index
-10.5 ° (C=0.4, CHCl3)
storage temp. 2-8°C
Biological Activity Antifungal agent; potent inhibitor of cytochrome P450c17.
Usage antifungal, PXR/SRC1 & CAR/SRC1 inhibitor
Usage For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Usage Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor
Items Specifications Results
Characters A white or almost white powder. almost white powder
Solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in methanol, sparingly soluble in alcohol. Qualified
Identification IR Qualified
Melting range 148°C~152°C 148°C~151°C
Specific rotation -1°~+1°
Loss on drying ≤0.5% 0.1%
Residue on ignition ≤0.1% 0.05%
Chromatographic purity ≤2.0% Qualified
Residual solvents acetoacetate≤0.5%
dimethyl sulfoxide≤0.5%
0.00%
0.00%
Assay 98.0%~102.0% 99.4%
Microbial Limit Bacteria  not more than 10 per g
Mold & yeast          Absent per g
Escherichia coli       Absent per g
Pseudomonas aeruginosa    Absent per g
Qualified
Conclusion The product complies to the standard of USP34.

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