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Latanoprost

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Packaging Details: 1g/bag, 1g/btottle
Delivery Detail: prompt shipment

Specifications:
PRODUCT NAME: Latanoprost
CAS NUMBER: 130209-82-4

solubility DMSO: freely soluble
storage temp.
-20°C Freezer
a prostaglandin F2a analogue Latanoprost is a prostaglandin F2a analogue.It is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor.
It is used to treat certain kinds of glaucoma(open-angle glaucoma ocular hypertension). It is also used to treat a condition called hypertension of the eye. Latanoprost is used to increase the natural outflow of fluid (aqueous humor) from inside the eye into the bloodstream. It appears to work by increasing the outflow of fluid from the eye. This lowers the pressure in the eye.
Latanoprost may make your eyesight blurred for a short length of time. if this happens do not drive or operate machine or use any tools until your eye sight becomes clear again.
Latanoprost ophthalmic solution Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.
It is also known by the brand name of Xalatan manufactured by Pfizer.For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Latanoprost ophthalmic solution contain a preservative called benzalkonium chloride which can be absorbed onto the surface of contact lenses and may discolour soft contact lenses.
Side effects Between 6% and 10% (between 1 in 20 and 1 in 6) of persons receiving latanoprost for 6 months report at least one side effect localized to the eyes. These side effects included Temporary blurred vision after application, eyelid redness, permanently darken eyelashes,Swelling or erosions of the cornea,a sensation of a foreign body, discoloration of the iris, itching, a temporary burning sensation during use, and stinging. Discoloration of the iris begins happens slowly. It is caused by an increase in the amount of brown pigment in the iris and may be permanent. Other side effects which have been reported less frequently include dryness of the eyes, increased tearing, herpes simplex keratitis, eye pain and other eye-related discomfort.
Usage antifungal polyene macrolide that is active in the cell membrane soluble 5% Acetic acid
Usage Prostaglandin analog, used to treat glaucoma and other degenerative diseases of the eye.
Items Specifications Results
Description pale yellow to colorless Oil pale yellow Oil
Identification HPLC  NMR Conform
Solubility Freely soluble in Isopropanoll and methanol Conform
Apperanceof solution pale yellow to colorless in Isopropanol Conform
Specific Rotation + 32° ~ + 38°(C=10mg/ml  Acetonitrile) + 34.7°
Water ≤ 0.5 % 0.23%
Residue on ignition ≤ 0.1% 0.04%
Heavy metals ≤ 10ppm Conform
Related substances 15(S)-cis isomer:   ≤ 0.1%
15(S)-trans isomer: ≤ 0.1%
15(R)-trans isomer: ≤ 0.1%
15-kero≤ 0.1%
Any other impurity: ≤ 0.1%
Total other impurities:≤ 1.0%
0.08%
0.04%
0.06%
Not detectable
0.04%
0.11%
Residue Solvent n-Hexane:≤ 0.029%
Ethanol: ≤ 0.5%
Methanol:≤ 0.3%
Isopropanol ≤ 0.5%
Not detectable
0.25%
Not detectable
Not detectable
Purity by HPLC 99.0%~105% 99.71%

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