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Naproxen

Naproxen

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Package and Storage:

Packaging Details: 25kg/drum
Delivery Detail: One week

Specifications:
Naproxen Standard: BP2010

MP 152-154 °C(lit.)
refractive index 67.5 ° (C=1, CHCl3)
storage temp.
-20°C Freezer
Non-steroidal anti-inflammatory drugs Naproxen is a non-steroidal anti-inflammatory drug ,it is a PG synthase inhibitor, which can inhibit prostaglandin synthetase, it has significant analgesic and antipyretic effects, oral absorption is rapid and complete, 2 to 4 hours after a dose ,plasma concentration reaches the peak, in the blood , more than 99% is bound to plasma proteins, t1 / 2 is 13 to 14 hours, about 95% is discharged from the urine with the prototype and metabolites.it is clinically used For the treatment of rheumatic and rheumatoid arthritis , osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.it can also be used to alleviate pain caused by musculoskeletal sprains, contusions,damages and dysmenorrhea . But it should be noted that like other non-steroidal anti-inflammatory drugs, the same serious gastrointestinal adverse reactions could occur at any time while taking naproxen during treatment, so the active gastroduodenal ulcer patients are hanged, other gastrointestinal tract disease patients should take this drug under close medical supervision.
Chemical Properties White crystal or crystalline powder. Melting point 155.3 ℃. Soluble in acetone, soluble in methanol, ethanol, acetic acid, insoluble in benzene, practically insoluble in water. In case of light,it is color-graded, odorless, tasteless.
Toxicity grading Highly toxic
Acute toxicity Oral – rat LD50 248 mg/kg; Oral – Mouse LD50: 360 mg/kg
Flammability and hazard characteristics Combustible; combustion produces toxic and acrid smoke.
Storage Characteristics Ventilated, low-temperature ,dry storeroom, it should be stored and transported from food raw materials separately.
Extinguishing agent Water, dry powder, foam,sand
Application It is a non-steroidal anti-inflammatory drug for the relief of fever and inflammation and pain associated with arthritis or other symptoms , it has anti-inflammatory, antipyretic and analgesic effects. Naproxen plays a role by inhibiting the cyclooxygenase, which generates prostaglandin and is one kind of enzymes related to inflammatory mediators . It is recommended to take the drug during meals to reduce stomach irritation.
Usage An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
ITEMS SPECIFICATIONS RESULTS
Characters A white or almost white crystalline powder Comply
Specific optical rotation 59° ~ 62° 60.1°
Melting point 154.0~158.0°C 156.0~156.5°C
Specific absorbance Meet the requirements Comply
Infrared absorption Meet the requirements Comply
Appearance of solution Clear,not more intense than BY7 Comply
Eantiomeric purity ≤2.5% 0.70%
Related substances
Impurity L ≤0.1% <0.01%
Unspecified impurities ≤0.1% 0.02%MAX
Total impurities ≤0.3% 0.04%
Heavy metals ≤20ppm <20ppm
Loss on drying ≤0.5% 0.01%
Sulphate ash ≤0.1% 0.01%
Assay 99.0%~101.0% 99.70%

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