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Packaging Details: 25kg/drum
Delivery Detail: One week

Norfloxacin is an antibiotic used to treat certain infections caused by bacteria, such as prostate, and urinary tract infections.
Store it at room temperature and away from excess heat and moisture .Packing: 25kgs drum/ aluminium tin or as required.

MP 220°C
storage temp.
Anti-infection drug Norfloxacin is a quinolone-class anti-infective drug with high degree of antibacterial activity against Escherichia coli, Shigella, Salmonella, Proteus, Pseudomonas aeruginosa and other gram-negative bacteria as well as excellent antibacterial effect against Staphylococcus aureus, pneumococcus bacteria and other Gram-positive bacteria. Its major site of action is in the bacterial DNA gyrase, causing the rapid cracking of the bacteria DNA helix and rapidly inhibiting the bacterial growth and reproduction, finally killing the bacteria. Moreover, it has a strong penetration capability into the cell walls so that it has a stronger bactericidal effect with a small stimulation on the gastric mucosa.
It is clinically used for treating the susceptible strains caused infection diseases in urinary tract, intestinal, ENT, gynecology, surgery and dermatology with the major indications as follows:
1, genitourinary infections: simple and complicated urinary tract infections, bacterial prostatitis, gonococcal urinary tract infections and reproductive tract infections.
2, gastrointestinal tract infections.
3, typhoid and other Salmonella infections.
Norfloxacin is a concentration-dependent drug which means that the in vivo concentration of the drug is directly proportional to the in vivo efficacy of the drug. The higher the concentration is, the better effect is. As the food will slow down the absorption rate of norfloxacin in the human body, the plasma concentration in the case of taking it before meals (with empty stomach) is 2-3 fold of that in the case of taking it after a meal; therefore, taking it after the meal will greatly reduce the efficacy and may also lead to the drug resistance issue of the susceptible bacteria to the norfloxacin and other similar antimicrobial drugs.
Chemical Properties It is white to light yellow crystalline powder. It is odorless with slightly bitter taste. Upon exposure to the air, it can easily absorb moisture to form a hemihydrate. Its color will be deepened upon light. Solubility (mg / m1) in 25 ℃: 0.28 in water, 0.98 in methanol, 1.9 in ethanol, 5.1 in acetone, 5.5 in chloroform, 0.01 in diethyl ether, 0.15 in benzene, 0.94 in ethyl acetate, 5.1 in octanol, and 340 in glacial acetic acid. It is easily soluble in acidic or alkaline solution and slightly soluble in dimethylformamide. Its solubility in the water depends on the pH value and increases rapidly within the range of at pH <5 or pH> 10. It has a melting point of 218-224 ℃. It has also been reported of a melting point of 220-221 ℃. The maximum UV absorption (0.1mol / L sodium hydroxide solution): about 274,325.336nm (A has a height of about 1109, 437, 425). pKal 6.34; pKa2 8.75. Acute toxicity LD50 in mice, rats (mg / kg): All> 4000 oral administration; all hypodermic 1500; 470,> 500 intramuscular injection; 220,270 intravenous injection.
Toxicity grading poisoning
Acute toxicity intravenous – rat LD50: 245 mg/kg; Oral – Mouse LD50: 4000 mg/kg
Flammability and hazardous characteristics it is combustible with combustion produces toxic fumes of nitrogen oxides and fluorides; Side effect when patients take it: musculoskeletal functional changes
Storage Characteristics ventilation low-temperature and dry
Extinguishing agent Dry powder, foam, sand, carbon dioxide, water spray
Application Norfloxacin belongs to third-generation quinolone antibacterial agent developed by Japanese Kyorin Company in 1978. It has features of broad antibacterial spectrum and strong antibacterial activity. It has a strong antibacterial effect against Escherichia coli, pneumobacillus, Aerobacter aerogenes, and Aerobacter cloacae, Proteus, Salmonella, Shigella, Citrobacter and Serratia. It is clinically used for treating the susceptible strain’s causing infections of urinary system, intestinal, respiratory system, surgery, gynecology, ENT and dermatology. It can also be used for the treatment of gonorrhea.
Usage Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.

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