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Ondansetron HCl

Ondansetron HCl

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Packaging Details: 25 kilos/drum
Delivery Detail: Within 7days after confirmation

Specifications:
PRODUCT NAME: Ondansetron HCl
CAS NUMBER: 146475-23-2/146844-89-5
Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic, often following chemotherapy. It affects both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.

Test items Standard Result
Description White or almost white crystalline powder white crystalline powder
Solubility Slightly soluble in water ,very slightly soluble in methanol, practically insoluble in ethano Complies
Identification IR vs standard
Test for specific optical rotation
Complies
Complies
Appearance of solution The solution is clear and colorless Complies
Acidity Not more than 0.6ml of 0.01M Naoh is required to change the color of  the indicator to pink 0.44ml
Specific optical rotation +74.5°~+78.0° +75.6°
Related substances Impurity A: NMT0.1%
Impurity B: NMT0.1%
Impurity C: NMT0.1%
Any other impurity: NMT0.1%
Total of other impurities: NMT0.1%
Total of impurities: NMT0.3%
0.03%
0.05%
0.03%
0.05%
0.06%
0.16%
Impurity D NMT0.1% 0.01%
Silver NMT5ppm <1ppm
Loss on drying NMT0.5% 0.19%
Assay 98~102% (dried substance) 99.85%
Bacterial Endotoxins <1.0IU/mg Complies

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