HOME > Orlistat
|Packaging Details:||25 kg in Drum, 2g5/50g/100g/250g in Aluminum foil bags|
|Delivery Detail:||10-30 DAYS|
|Solubility||DMSO: 19 mg/mL|
|Appearance||white to white crystalline powder, soluble in methanol, ethanol, acetone and ether, almost insoluble in water|
|Maximum impurity||≤ 0.5%; ≤ 0.2%|
|Total impurities||≤ 2.0%; ≤ 1.0%|
|Content||≥ 98% by HPLC; ≥ 99% by HPLC|
|Biological Activity||Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo.|
|Usage||Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.|
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