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Orlistat

orlistat

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Package and Storage:

Packaging Details: 25 kg in Drum, 2g5/50g/100g/250g in Aluminum foil bags
Delivery Detail: 10-30 DAYS

Specifications:
PRODUCT NAME: Orlistat (Tetrahydrolipstatin)

MP <50 °C
storage temp.
2-8°C
Solubility DMSO: 19 mg/mL
Appearance white to white crystalline powder, soluble in methanol, ethanol, acetone and ether, almost insoluble in water
Maximum impurity ≤ 0.5%; ≤ 0.2%
Total impurities ≤ 2.0%; ≤ 1.0%
Content ≥ 98% by HPLC; ≥ 99% by HPLC
Biological Activity Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo.
Usage Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.

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