HOME > Oxaliplatin
|Packaging Details:||As required|
|Delivery Detail:||prompt shipment|
|Stability||Stable. Store cool. Incompatible with oxidizing agents.|
||Store at +4°C|
|Adverse reactions and side effects||
1, the hematopoietic system: oxaliplatin has some hematologic toxicity. When administered alone,it can cause the following adverse reactions: anemia, leukopenia, neutropenia, thrombocytopenia, sometimes up to grade 3 or 4. When in combination with 5-fluorouracil , neutropenia and thrombocytopenia diseases’ hematological toxicity increases .
2, the digestive system:When administered alone, it can cause nausea, vomiting, diarrhea. These symptoms sometimes are very serious. When in combination with 5-fluorouracil, these side effects are increased significantly. It is Recommended to give preventive and / or therapeutic anti-emetic medication .
3,the nervous system: peripheral neuritis, characterized by peripheral sensory neuropathy. Sometimes there are accompanied around the mouth, upper respiratory tract and upper digestive tract spasms and sensory disorders.
|Chemical Properties||Triangular flaky colorless crystals. The water solubility is 7.9mg/ml.|
|Biological Activity||Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.|
|Application||For the treatment of colorectal cancer.|
|Usage||Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.|
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