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Oxaliplatin

Oxaliplatin

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PRODUCT NAME: Oxaliplatin
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Stability Stable. Store cool. Incompatible with oxidizing agents.
storage temp.
Store at +4°C
Adverse reactions and side effects 1, the hematopoietic system: oxaliplatin has some hematologic toxicity. When administered alone,it can cause the following adverse reactions: anemia, leukopenia, neutropenia, thrombocytopenia, sometimes up to grade 3 or 4. When in combination with 5-fluorouracil , neutropenia and thrombocytopenia diseases’ hematological toxicity increases .
2, the digestive system:When administered alone, it can cause nausea, vomiting, diarrhea. These symptoms sometimes are very serious. When in combination with 5-fluorouracil, these side effects are increased significantly. It is Recommended to give preventive and / or therapeutic anti-emetic medication .
3,the nervous system: peripheral neuritis, characterized by peripheral sensory neuropathy. Sometimes there are accompanied around the mouth, upper respiratory tract and upper digestive tract spasms and sensory disorders.
Chemical Properties Triangular flaky colorless crystals. The water solubility is 7.9mg/ml.
Biological Activity Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.
Application For the treatment of colorectal cancer.
Usage Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.

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