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paracetamol

4-Acetamidophenol

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Package and Storage:

Packaging Details: 25 KG DRUM/BAG
Delivery Detail: Within 7days after confirmation

Specifications:
PRODUCT NAME: paracetamol
CAS NUMBER: 103-90-2

MP 168-172 °C(lit.)
Density 1,293 g/cm3
FP 11 °C
storage temp.
Store at RT
Water Solubility 14 g/L (20 ºC)
General Description Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about 6.
Air & Water Reactions Slightly soluble in water.
Reactivity Profile 4-Acetamidophenol is sensitive to light. Incompatible with strong oxidizers.
Fire Hazard Flash point data for 4-Acetamidophenol are not available; however, 4-Acetamidophenol is probably combustible.
Biological Activity Cyclooxygenase inhibitor; may be selective for COX-3 (IC 50 values are 460, > 1000 and > 1000 μ M for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
Usage Analgesic; antipyretic; dispersing agent in liquid scintillation counting
Analysis Test Specification Result
Description White or almost white ,crystalline powder. White,crystalline powder.
Identification Melting point: 168-172ºC
IR absorption: Complies
169.3-170.4ºC
Complies
Related substances 6.0~7.5 6.9
Solution clarity and color solution should be clear and colorless Conforms
Related substances Impurity J(chloroacetanilide)not more than 10 ppm
Impurity K(4-aminophenol)not more than 50 ppm
Impurity F(4-nitrophenol)not more than 0.05%
any other impurity not more than 0.05%
Total of other impurities not more than 0.1%
1ppm
5ppm
Not detected
0.04%
0.07%
Sulfated ash Not more than 0.1% 0.06%
Particle sizer Pass 400 mesh Complies
Heavy metals Not more than 20ppm Less than 20ppm
Loss on drying Not more than 0.5% 0.1%
Assay 99.0-101.0% (dried substance) 99.2%
Residual solvents Residual content of acetic acid is limited by the test of loss on drying not more than 0.5% Less than 0.5%
Conclusion Complies with EP7

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