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Poloxamer is a synthetic block copolymer of ethylene oxide and propylene oxide. It is available in several types, conforming to the following requirements.
This kind of surfactant were firstly developed by America.They have almost no toxicity, little irritation on the skin and the mucosa. They are widely used as emulsifier, solubilizing agent, hydrophilic substrate of ointments and suppositories,artificial blood, artificial tear and artifical skin etc.

MP 57-61 °C
BP >200 °C(lit.)
Density 1.095 g/mL at 25 °C
Vapor density >1 (vs air)
Vapor pressure <0.3 mm Hg ( 20 °C)
refractive index n20/D 1.466
storage temp.
Solubility H2O: at <70 °Csoluble
Usage Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.

Executed Standard(CP2000)

Tradename F-68 F-88 F-98 F-108 F-127
Unsaturation(meq/g) 0.065±0.035 0.065±0.035 0.065±0.035 0.065±0.035 0.065±0.035
Average Molecular Weight 8350±1000 10800±1000 13500±1000 15500±1000 11500±1000
Melt point 50±2 55±5 56±2 57±2 56±2
Heavy metal content(ppm, max) 20 20 20 20 20
Arsenic salt(%, max) 0.0002 0.0002 0.0002 0.0002 0.0002
PH 5-7.5 5-7.5 5-7.5 5-7.5 5-7.5

Executed Standard(USP24.NF19)(Poloxamer)

Tradename 124 188 237 338 407
Unsaturation(meq/g) 0.020±0.008 0.025±0.008 0.034±0.008 0.031±0.008 0.048±0.008
Molecular Weight 2090-1000 7680-9510 6840-8830 12700-17400 9840-14600
EO content(%) 40.7±1.9 81.8±1.9 72.4±1.9 83.1±1.7 73.2±1.7
Heavy metal content(ppm, max) 20 20 20 20 20
Arsenic salt(%, max) 0.0002 0.0002 0.0002 0.0002 0.0002
PH 5-7.5 5-7.5 5-7.5 5-7.5 5-7.5

Application: F-127 gel can be used as carrier for controlling and realsing anticancer drug, for medicine applied to rectum for diminishing inflammation and relieving pain. Iit is also used for the controlled and released medicine which is applied to the mucosa of navity and vagina.
F-68 can be used as defoaming agent for blood circulation in the artificial heart-lung machine in order to prevent the air from entering the blood of the patient,decrease the formation of formation of foam and increase oxygenation. In LIPOMUL(manufactured by Upjohn Corp. of America), as an emusifier, it is used , in combination with soya phophatide, for preparing fat emulsion infusion for intravenous injection. In the production of solid dispersion medicine, as a carrier, it can greatly enhance the rate of dissolving out and biological utilization of the medicine. It is relatively ideal quick-acting carrier for solid dispersion.
Package,storage and transportation: It should be packed in PP drum(with plastic bag lining(,the net weight is 25kg or 50kg, and shoule be free from exposure to the sun,high temperatureand moisture.Naked flame is strictly prohibited. During transport,it should avoid being violently clashed in order to prevent damage. Its quality can be guaranteed for 2 years during storage.
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