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Prednisolone

Prednisolone

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Product name: Prednisolone / CAS: 50-24-8
Prednisolone is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions. It is the active metabolite of the drug prednisone and is used especially in patients with hepatic failure, as these individuals are unable to metabolise prednisone into prednisolone.

Items Specifications
MP
240 °C (dec.)(lit.)
refractive index 100 ° (C=1, Dioxane)
storage temp. -20°C Freezer
Character
White or almost white crystalline powder
Specific rotation
+96° TO +102°
Identification
A.complies by IR
B.Complies by TLC
Related substances
Not more than one impurity between 0.5% TO 1.0%
Total impurity not more than 2.0%
Loss on drying
Not more than 1.0%
Particle size
It should be 90% below μm
Assay
It should contain 97.0 to 103.0% of C21H28O5 calculated on dried basis
Usage
Synthetic corticosteroid; metabolically interconvertible with prednisone
Usage
substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor

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