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Repaglinide

Repaglinide

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Product name: Repaglinide / CAS: 135062-02-1
Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the beta cells. This depolarizes the beta cells, opening the cells’ calcium channels, and the resulting calcium influx induces insulin secretion.

Items Specifications
MP
129-130.2 °C
storage temp. 2-8°C
solubility DMSO: 34 mg/mL
Biological Activity
K ATP channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (K d = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.
Usage
Non-sulfonylurea oral hypoglycemic agent. Used as an antidiabetic
Usage
The R-enantiomer showed only weak hypoglycemic activity. Repaglinide impurity

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