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Sodium Valproate

Sodium Valproate

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PRODUCT NAME: Sodium Valproate
CAS NUMBER: 1069-66-5
Sodium valproate is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy, anorexia nervosa, panic attack, anxiety disorder, posttraumatic stress disorder, migraine and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer. Sodium valproate can be used to control acute episodes of mania and acute stress reaction. Side effects can include tiredness, tremors, nausea, vomiting and sedation.[1] The intravenous formulations are used when oral administration is not possible. .

MP 300 °C
storage temp.
Desiccate at RT
solubility H2O: 50 mg/mL
Water Solubility soluble
Biological Activity Histone deacetylase inhibitor (IC 50 = 400 μ M) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases A β production in animal models of Alzheimer’s disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na + channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2.
Usage Antiepileptic; increases levels of GABA in the brain
ITEMS SPECIFICATIONS RESULTS
Characteristics A white or almost white crystalline powder A white or almost white crystalline powder
Identification Positive Positive
Acidity And Alkatinity ≤0.75ml0.1MnaOH or 0.1M HCl 0.1MHCl 0.1ml
Clarity and Colour of Solution ≤Reference SuspensionII≤Y6 <Reference SuspensionII<Y6
Heavy Metals ≤20ppm <20ppm
Chloride ≤200ppm <200ppm
Sulphate ≤200ppm <200ppm
Loss on Drying ≤2.0% 0.4%
Free valproic acid ≤1.0% <1.0%
Assay ≤98.5-101.0% 100.5%
Total impurity ≤0.3% <0.3%
Any dividual impurity ≤0.1% <0.1%
Any related Substances ≤0.1% <0.1%
Conclusion IT CONFORMS TO BP2000

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